DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability
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چکیده
منابع مشابه
Author's response to reviews Title:DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability Authors:
Yuta Muto ([email protected]) Takafumi Maeda ([email protected]) Koichi Suzuki ([email protected]) Takaharu Kato ([email protected]) Fumiaki Watanabe ([email protected]) Hidenori Kamiyama ([email protected]) Masaaki Saito ([email protected]) Kei Koizumi ([email protected]) Yuichiro Miyaki ([email protected]) Fumio Konishi ([email protected]) Sergio Alon...
متن کاملConventional colon adenomas harbor various disturbances in microsatellite stability and contain micro-serrated foci with microsatellite instability
INTRODUCTION Colorectal cancer belongs to the most frequent occurring malignancies. A prediction of the clinical outcome and appropriate choice of neoadjuvant chemotherapy needs personalized insight to the main driving pathways. Because most CRCs have polyps as progenitor lesions, studying the pathways driving to adenomagenesis is no less important. GOALS Our purpose was the evaluation of mic...
متن کاملThymidylate synthase expression in colon carcinomas with microsatellite instability.
PURPOSE Colon cancer cells with high-frequency microsatellite instability (MSI-H) display resistance to 5-fluorouracil (5-FU) that can be reversed by restoring DNA mismatch repair (MMR) proficiency. Given that thymidylate synthase (TS) is inhibited by 5-FU, we studied the relationship between MSI and TS expression, and the prognostic effect of these and other markers (i.e., p53 and 17p allelic ...
متن کاملDietary factors and microsatellite instability in sporadic colon carcinomas.
Microsatellite instability (MSI) occurs in 10-20% of the sporadic colon carcinomas and appears to be primarily due to alterations in hMLH1 and hMSH2. Little is known about the role of diet in MSI-related colon carcinogenesis. We used data from a Dutch population-based case-control study on sporadic colon carcinomas (184 cases and 259 controls) to evaluate associations between dietary factors pr...
متن کاملDNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?
AIM To investigate the distribution of DNA microsatellite instability (MSI) in a series of hyperplastic polyps, serrated adenomas, and mixed polyps of the colorectum. METHODS DNA was extracted from samples of 73 colorectal polyps comprising tubular adenomas (23), hyperplastic polyps (21), serrated adenomas (17), and mixed polyps (12). The presence of MSI was investigated at six loci: MYCL, D2...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2014
ISSN: 1471-2407
DOI: 10.1186/1471-2407-14-466